Research and Publications

Scientific Biography

My scientific biography reflects my career as an academic cardiothoracic surgeon. Over the years I was engaged both in clinical and basic science research. In both areas I focused on topics that are close and relevant to my clinical practice. Collaboration with other disciplines was key to achieve high-quality research.

The early phase of my clinical research is characterized by a series of retrospective analyses of cohorts of patients that were unique because of clinical presentation, the surgical procedure, or unusual complication. Typically these studies were single-center retrospective studies. Most of these studies included evaluation of long-term outcomes with follow-up of ten years or longer. Examples of such studies include assessment of the long-term outcome of patients undergoing allograft aortic valve replacement using various techniques (Ref. # 11, 12, 13), comparison of linear repair vs. endoaneurysmorrhaphy for left ventricular aneurysm (Ref. # 19), long term outcomes of patients undergoing coronary endarterectomy (Ref. # 35), outcomes of valve surgery in the elderly (Ref. # 22) and more.

Another category of clinical studies include those I initiated to assess our institutional experience with a new technique. Examples include evaluation of our initial results with the use of the radial artery for coronary artery bypass grafting (Ref. # 27), the use of heparin-bonded cardiopulmonary bypass circuits and reduced systemic anticoagulation in patients undergoing valve surgery (Ref. # 18) or complex aortic operations (Ref. # 39) and the use of U-Clips™ for coronary anastomoses (Ref.# 43).

At a later stage I started to design, conduct and participate in single-center prospective randomized trials aimed to answer specific clinical questions. Typical examples in this category include a study evaluating the impact of reduction of cardiopulmonary bypass prime volume on transfusion and clinical outcomes of patient undergoing cardiac surgery (Ref. # 24), comparison of Diltiazem and Nitroglycerin in the prevention of radial artery spasm in patients undergoing coronary artery bypass grafting (CABG) (Ref. # 36), the role of calcium (Ref. # 42) or GIK (Ref. # 54) in the prevention of post CABG diastolic dysfunction and comparison of heparin-bonded and conventional cardiopulmonary bypass circuits in patients undergoing CABG (Ref. # 17). In many of these studies I was the Principal Investigator. Some of these studies had a major impact on clinical practice, at least in the United States. Examples include the conversion to IV nitroglycerin in the 1st 24 hours post- CABG to prevent radial artery spasm by many surgeons, the adoption of “retrograde autologous priming” method and switching to heparin-bonded cardiopulmonary bypass circuits.

More recently I became more involved in multi-center prospective randomized trials in which I am a Co-investigator. Examples include the NIH-sponsored STICH trial evaluating medical versus surgical treatment of patients with ischemic heart disease and poor left ventricular ejection fraction, the NIH-sponsored FREEDOM trial comparing percutaneous coronary interventions (PCI) with drug-eluting stents and CABG in diabetic patients with multi-vessel disease and the randomized, double-blind placebo-controlled study of the safety and efficacy of human recombinant soluble complement receptor Type 1 (TP-10) inhibitor in adult women undergoing CABG (Ref. # 55).

There is no doubt that I will continue to be engaged in clinical research. My current projects include a retrospective study comparing minimally invasive vs. conventional aortic valve replacement, a prospective randomized trial comparing single and biventricular pacing modes in patients undergoing CABG, and others. I am also looking at expanding the scope of my clinical research to include more epidemiology and process improvement. One example is an on-going study I initiated as the Principal Investigator in collaboration with the Massachusetts General Hospital and the Harvard School of Public Health evaluating the impact of race, health insurance and socioeconomic status on utilization rates and outcomes after CABG and PCI in the Commonwealth of Massachusetts. An abstract of preliminary results of this work was recently presented at the American Heart Association Annual Scientific Sessions.

It is my strong belief that an academic surgeon should be engaged in basic science research in areas related to the specialty. During my General Surgery training anticipating a career path that will include organ transplantation, I embarked in research in the field of transplantation immunology. I spent 2 1/2 years at the Weizmann Institute of Science and used a model of heterotopic heart transplantation in rats to conduct two separate studies assessing the effect of T-cell vaccination (Ref. # 9) and mini doses of low molecular weight heparin (Ref. # 31) on allograft survival with very encouraging results.

Shifting my focus to cardiovascular surgery and practicing in a setting not engaged in organ transplantation my research interests have changed. During the past decade my basic research is focused on vascular biology. In an attempt to identify physiological factors explaining the superior long-term patency of arterial conduit compared to vein grafts I initiated a collaborative study characterizing the Nitric Oxide (NO) system in human internal mammary artery, radial artery and saphenous vein, the most commonly used conduits for CABG. We showed that arterial conduits produce significantly more NO in response to receptor-mediated and non-receptor mediated stimuli (Ref. # 34).

In another study we evaluated the effect of different vasodilators on the radial artery (Ref. # 30). In an initial set of experiments using organ-chamber methodology we demonstrated that nitroglycerin is a much more potent radial artery vasodilator compared to the calcium channel antagonist Diltiazem. We then extended these in-vitro experiments into a study in volunteers with known CAD. We infused the tested drug in one arm and used high resolution ultrasound to assess the vasodilatory effects of the drugs on the contra-lateral radial artery. The results of these studies formed the base of a clinical prospective randomized trial (Ref. # 36).

To better understand the human vascular NO system and the signaling mechanisms involved in its activation / suppression I collaborated with our cardiologist group in another set of experiments. We have studied the effects of black tea polyphenols on endothelial cells and identified p38 MAP kinase as a key component of eNOS activation (Ref. # 46). In a related study we have shown that black-tea activation of eNOS via MAP kinase is dependent on estrogen receptor alpha pathway (Ref. # 47).

In line with my deep interest in the vascular biology of commonly used coronary artery bypass conduits and my desire to characterize the ideal conduit, I participated in a series of experiments in collaboration with the Boston Children’s Hospital and Harvard Medical school implementing techniques of tissue engineering to construct small-caliber blood vessels. The first step was to create a vessel skeleton devoid of cellular components. In a feasibility study we coated these skeletonized vessels consisting of extra-cellular matrix only with human endothelial cells obtained from saphenous vein segments harvested during CABG operation (Ref. # 52). We then used this concept in a sheep model (Ref. # 38). We used extra-cellular matrix small vessels as the scaffold and coated them with circulating progenitor endothelial cells. We were able to show in vitro that these genetically-engineered vessels had many of the histological and physiological characteristics of native vessels with active live endothelium. We then grafted these vessels in sheep and demonstrated excellent patency up to 3 months post grafting.

I plan to continue to be engaged in basic science research. In fact, this was one of the main factors that stimulated my interest in Hadassah Medical Center, being aware of the strong research programs in the hospital and the proximity to the Medical School. The Department of Cardiothoracic Surgery at Hadassah Medical Center has traditionally been involved in research, having an active laboratory in collaboration with the Division of Cardiology. I hope to continue some of the on-going studies. In one such project our group is currently evaluating another important system that plays a major role in vascular homeostasis – the natriuretic peptide system. We characterize the response of different vessels to different natriuretic peptides, assess the mechanisms of activation and possible interaction with the NO system, and examine the expression of the natriuretic peptide receptors. Similar to this line of investigations we are exploring the use of proteomic techniques to characterize the different vessels. In another NIH-sponsored four-year study we are currently evaluating the determinants of shear-stress-mediated arterial remodeling using the changes in the ulnar artery that occur after harvesting the ipsi-lateral radial artery with the contra-lateral arm serving as the internal control. In addition to evaluation of impact of various clinical factors we are investigating the correlation of shear-stress-induced arterial remodeling with endothelial function at various levels including mitochondrial function, circulating endothelial cells and other possible factors.

It is very difficult to summarize more than two decades of clinical and basic science research. More than the details of one study or other I hope that I was able to convey my deep commitment to both clinical and basic science research. Research is an integral part of my professional career.

Research Grants

1998 – 2000: M. Yanai grant (Private), The impact of slow-release VEGF on angiogenesis, left ventricular hypertrophy and the development of heart failure in Dahl salt-sensitive hypertensive rats. Role: PI, $50,000 / $50,000.

2004 – 2006: Ethicon, Inc., Endoscopic vs. conventional radial artery harvest: Functional and histological assessment of the Conduit. Role: PI. $84,000 / $84,000, #48.

2006 – 2010: United States National Institute of Health (RO1 grant). The effect of shear stress on ulnar artery remodeling. Role: Co-investigator. Sum: 1.4 m. No specific designation to each of the investigators.

Teaching at Boston University School of Medicine

1) Master students

2004 – 2005 Chey V. Collura, Co-supervisor – Abdulmaged Traish, MD, PhD, Professor of Surgery, degree completed, #27 (published abstracts).

2005 – 2006 Michael J. Hagar, Co-supervisor – Theresa A. Davis, PhD, Assistant Professor of Biochemistry, degree completed.

2006 – 2007 Margaret Tejani, Co-supervisor – Theresa A. Davis, PhD, Assistant Professor of Biochemistry, degree completed.

2) Courses

1998 – 2007: Introduction to Clinical Medicine I (ICM-1), twelve 3-hour meetings / semester with 1st year BUSM students in an outpatient clinical setting.

1998 – 2007: Introduction to Clinical Medicine II (ICM-2), twelve 3-hour meetings / semester with 2nd year BUSM students in an outpatient clinical setting.

3) Associate Program Director of the Cardiothoracic Surgery Residency Training Program, Boston University School of Medicine.

Daily direct supervision and teaching in the operating room, clinical rounds and Departmental teaching conferences
Development of teaching curriculum
Organizing the Department of Cardiothoracic Surgery Weekly conference. The conference is structured to include Monthly Morbidity and Mortality conference, Monthly Journal Club, “Wet” labs, invited speakers, weekly discussions on cardiac and thoracic topics covering the entire Thoracic Surgery Directors Association (TSDA) core curriculum, including the 6 core-competencies such as ethics, professionalism etc.
Arrangement of special lectures and invited speakers
Identify resources such as web-based lectures, teaching symposia and others to enhance education related to the six core-competencies
Distribute teaching material related to impact of fatigue on performance and carefully monitor compliance with new regulations regarding 80-hour / week
Participation in the institutional GME committee
Six-months evaluation sessions with each resident
Teaching 3d year BUSM during Cardiothoracic Surgery Rotations.
1995 – 2007: Clinical rounds and OR teaching of 3d year BUSM students during Cardiothoracic Surgery rotations. Ten to fifteen students / academic year.

4) Introduction to clinical research

One-three year research projects with 1st to 3d year BUSM students introducing clinical research principles to medical students interested in academic careers. Topics covered: study design, power analysis, the ethical issues of informed consent, patients rights and confidentiality, principles of data collection, basic data analysis and manuscript preparation. (Examples – G. Akopian #35 , JD Alkon # 27, #36, RV Pawar #43, N Hao, Abstract #27).

List of Publications

Last updated April 2007

DOCTORAL DISSERTATION

Title: Electrocardiographic changes and cardiac arrhythmias before and during 24 hours after dialysis in chronic hemodialysis patients. Advisor: Y. Bar-Khayim M.D., Head of Nephrology Unit, Kaplan Hospital, Rehovot, Israel. Publication Date: June 1984, Article #7.

BOOKS

1. Murphy R, Shapira OM. Boston Medical Center, Department of Cardiothoracic Surgery House Staff Manual. 2001.

CHAPTERS IN COLLECTIONS

Shapira OM, Shemin RJ. Surgical revascularization after acute myocardial infarction. UpToDate in Medicine, Rose BD (ed), 1997: 5(3).

Shapira OM, Shemin RJ. Left ventricular aneurysm following acute myocardial infarction. UpToDate in Medicine, Rose BD (ed), 1998: 6(1).

Shapira OM, Shemin RJ. Surgical treatment of left ventricular aneurysm. UpToDate in Medicine, Rose BD (ed), 1998: 6(1).

Shapira OM, Shemin RJ. Surgery for acute myocardial infarction. In: Podrid PJ, Klein MD, Philippides GS (eds0, Coronary Care: Management of Acute Cardiac Problems, 1998.

Shapira OM. Congenital heart disorders. In: Essential of Surgery. Becker, JM (ed), EB Saunders, Co., 2000.

Murphy R, Shapira OM. Boston Medical Center – Department of Cardiothoracic Surgery manual of Postoperative Care. 2004.

Shapira OM. Surgical treatment of coronary artery disease. Part I – Cardiac anatomy. Thoracic Surgery Directors Association. Comprehensive Requisite Thoracic Surgery Curriculum. Unit VIII, section A1. Web chapter, 2004.

Shapira OM. Surgical treatment of coronary artery disease. Part II – Radiographic cardiac and coronary anatomy. Thoracic Surgery Directors Association. Comprehensive Requisite Thoracic Surgery Curriculum. Unit VIII, section A2. Web chapter, 2004.

Shapira OM. Surgical treatment of coronary artery disease. Part III – Pathologic development of the atherosclerotic plaque. Thoracic Surgery Directors Association. Comprehensive Requisite Thoracic Surgery Curriculum. Unit VIII, section A3. Web chapter, 2004.

Shapira OM. Surgical treatment of coronary artery disease. Part IV – Coronary artery bypass grafting surgery. Thoracic Surgery Directors Association. Comprehensive Requisite Thoracic Surgery Curriculum. Unit VIII, section A4. Web chapter, 2004.

Shapira OM. Surgical treatment of coronary artery disease. Part V – Preoperative evaluation. Thoracic Surgery Directors Association. Comprehensive Requisite Thoracic Surgery Curriculum. Unit VIII, section A5. Web chapter, 2004.

Shapira OM. Surgical treatment of coronary artery disease. Part VI – Postoperative care. Thoracic Surgery Directors Association. Comprehensive Requisite Thoracic Surgery Curriculum. Unit VIII, section A6. Web chapter, 2004.

Shapira OM. Surgical treatment of coronary artery disease. Part VII – Outcomes of surgery. Thoracic Surgery Directors Association. Comprehensive Requisite Thoracic Surgery Curriculum. Unit VIII, section A7. Web chapter, 2004.

Shapira OM, Shemin RJ. Left Ventricular aneurysm and pseudoaneurysm following acute myocardial infarction. UpToDate in Medicine,, Rose BD (ed), 2006.

ARTICLES

Original Papers in Peer Reviewed Journals

Shapira OM, Pasik S, Wassermann JP, Barzilai N, Mashiah A. (1990) Ultrasound screening for abdominal aortic aneurysms in patients with atherosclerotic peripheral vascular disease. J. Cardiovasc Surg. 31: 170-172. 0.8;60/72;25.

Mor E, Shapira OM, Simon D, Pfeffermann R. (1990) Nissen fundoplication for reflux esophagitis. Harefuah. 119: 297-300.

Simon D, Shapira OM, Pfeffermann R. (1991) The management of radiation induced injuries of the intestine. Harefuah. 120: 10-12.

Shapira OM, Simon D, Rothstein H, Mavor E, Pfeffermann R. (1992) Acute symptomatic hernia. Isr J Med Sci. 28: 285-288. 0.5;–;2

Mor E, Shapira OM, Merhav H, Mavor E, Pfeffermann R. (1992) Delayed operation for acute pancreatitis. Isr J Med Sci. 28: 779-782. 0.5;–;1

Simon D, Shapira OM, Mor E, Pfeffermann R. (1992) Parkinson syndrome – A significant risk factor in the patient with acute surgical disorder. Int Surg. 77: 313-316. 0.4;–;2

Shapira OM, Bar-Khayim Y. (1992) Electrocardiographic changes and cardiac arrhythmias in chronic renal failure patients on hemodialysis. J Electrocardiol. 25: 273-279. 0.9;58/72;34.

Shapira OM, Aldea GS, Shemin RJ. (1993) A simplified method for implantation of automatic cardioverter-defibrillator in patients with previous cardiac surgery. PACE. 16: 3-7. 1.3;45/72;1.

Shapira OM, Mor E, Reshef T, Pfeffermann R, Cohen IR. (1993) Prolongation of survival of rat cardiac allografts by T cell vaccination. J Clin Invest. 91: 388-390. 15.0;2/72;13

Shapira OM, Aldea GS, Fonger DJ, Shemin RJ. (1993) Video-assisted thoracic surgical techniques in the diagnosis and management of pericardial effusion in patients with advanced lung cancer. Chest. 104: 1262-1263. 4.0;3/20;12

Shapira OM, Shemin RJ. (1994) Aortic valve replacement with cryopreserved allografts-Mid-term results. J Cardiac Surg. 9: 292-297. 0.8;61/72;1.

Shapira OM, Shemin RJ. (1994) Allograft aortic valve replacement – A comparison of the free-hand technique versus root replacement. J Cardiovasc Surg. (suppl. 1): 35-40. 0.8;60/72;3.

Shapira OM, Fonger JD, Reardon K, Shemin RJ. (1995) Unexplained fever following aortic valve replacement with cryopreserved allografts. Ann Thorac Surg. 60: S151-155. 2.2;24/72;11.

Shapira OM, Kimmel WA, Lindsey PS, Shahian DM. (1996) Anterior ischemic optic neuropathy after open-heart surgery. Ann Thorac Surg. 61: 660-666. 2.2;24/72;16.

Aldea GS, Shapira OM, Patrick R, Treanor PR, Lazar HL, Shemin RJ. (1996) Effective use of heparin-bonded circuits and lower anticoagulation for coronary artery bypass grafting in Jehovah’s Witnesses. J Cardiac Surg. 11: 12-17. 0.8;61/72;11

Aldea GS, Zhang X, Memmolo CA, Shapira OM, Treanor PR, Kupferschmid JP, Lazar HL, Shemin RJ. (1996) Enhanced blood conservation in primary coronary artery bypass surgery using heparin-bonded circuits with lower anticoagulation. J Cardiac Surg. 11: 85-95. 0.8;61/72;7.

Aldea GS, Doursounian M, O’Gara P, Treanor PR, Shapira OM, Lazar HL, Shemin RJ. (1996) Heparin-bonded circuits with reduced anticoagulation protocol in primary CABG: A prospective randomized study. Ann Thorac Surg. 62: 408-410. 2.2;24/72;80.

Shapira OM, Aldea GS, Zellingher J, Volpe C, Fitzgerald CF, DeAndrade K, Lazar HL, Shemin RJ. (1996) Enhanced blood conservation and improved clinical outcome after valve surgery using heparin-bonded cardiopulmonary bypass circuits. J Cardiac Surg. 11: 307-317. 0.8;61/72;16.

Shapira OM, Davidoff R, Hilkert RJ, Aldea GS, Fitzgerald CA, Shemin RJ. (1997) Repair of left ventricular aneurysm – Long-term results of linear repair versus endoaneurysmorrhaphy. Ann Thorac Surg. 63: 701-705. 2.2;24/72;18.

Shapira OM, Cruz HA, Shemin RJ. (1997) Endarterectomy of the ascending aorta – An alternative method in patients with extensively calcified (porcelain) aorta requiring aortic valve replacement. J Cardiac Surg. 12: 160-164. 0.8;61/72;1.

Lazar HL, Jacobs AK, Aldea GS, Shapira OM, Lancaster D, Shemin RJ. (1997) Factors influencing mortality following emergent coronary bypass for failed percutaneous transluminal coronary angioplasty. Ann Thorac Surg. 64: 1747-52. 2.2;24/72;12.

Shapira OM, Kelleher RM, Zelingher J, Whalen D, Fitzgerald C, Aldea GS, Shemin RJ. (1997) Prognosis and quality of life after valve surgery in patients over the age of 75. Chest. 112: 885-894. 4.0;3/20;16.

Aldea GS, O’Gara P, Shapira OM, Treanor P, Osman A, Patalis E, Arkin C, Gendzier R, Babikian V, Lazar HL, Shemin RJ. (1998) Effect of anticoagulation protocol on clinical outcomes in patients undergoing CABG with heparin-bonded cardiopulmonary bypass circuits. Ann Thorac Surg. 65: 425-433. 2.2;24/72;46.

Shapira OM, Aldea GS, Treanor P, Chartrand R, DeAndrade K, Lazar HL, Shemin RJ. (1998) Reduction of homologous blood transfusion by lowering cardiopulmonary bypass prime volume – A prospective randomized study. Ann Thorac Surg. 65: 724-730. 2.2;24/72;29.

Aldea GS, Lilly K, O’Gara P, Stein D, Gaudiani JM, Bao Y, Treanor A, Osman A, Shapira OM, Lazar HL, Shemin RJ. (1998) Heparin-bonded circuits improve clinical outcomes in emergency CABG. J Cardiac Surg. 12: 389-397. 0.8;61/72

Aldea GS, Gaudinani J, Shapira OM, Jacobs AK, Lazar HL, Shemin RJ. (1998) Comparison of risk profile and outcomes in patients undergoing surgical and catheter based revascularization. J Cardiac Surg. 13: 81-89. 0.8;61/72;7

Shapira OM, Alkon JD, Aldea GS, Madera F, Lazar HL, Shemin RJ. (1998) Clinical outcomes in patients undergoing coronary artery bypass grafting with preferred use of the radial artery. J Cardiac Surg.12: 381-388. 0.8;61/72

Aldea GS, Gaudiani JM, Bao Y, Shapira OM, Jacobs A, O’Gara P, Lazar HL, Ryan TJ, Shemin RJ. (1999) Effect of gender on post-operative outcomes and hospital stays following CABG. Ann Thorac Surg. 67: 1097-1103. 2.2;24/72;43.

Shapira OM, Aldea GS, Cutter S, Fitzgerald C, Lazar HL, Shemin RJ. (1999) Improved clinical outcomes after surgery of the proximal aorta – A 10-year experience. Ann Thorac Surg. 67:1030-1037. 2.2;24/72;13.

Shapira OM, Xu A, Vita JA, Aldea GS, Shah N, Shemin RJ, Keaney JF. (1999) Nitroglycerin is superior to diltiazem as a coronary bypass conduit vasodilator. J Thorac Cardiovasc Surg. 117: 906-911. 3.7;9/72;42.

Shapira OM, Rene H, Lider O, Pfeffermann RA, Shemin RJ, Cohen IR. (1999) Prolongation of rat skin and cardiac allograft survival by low molecular weight heparin. J Surg Res. 85: 83-87. 2.0;30/139

Lazar HL, Bao Y, Lancaster D, Shapira OM, Aldea GS, Shemin RJ. (1999) Favorable impact of stents after emergency coronary artery bypass for failed angioplasty. Ann Thorac Surg. 68: 1644-1647. 2.2;24/72;2.

Shapira OM, Bonchek LI. (1999) Improved clinical outcomes after coronary endarterectomy. ACCEL. 51: 12.

Shapira OM, Xu A, Aldea GS, Vita JA, Shemin RJ, Keaney JF. (1999) Enhanced nitric oxide-mediated vascular relaxation in the radial artery compared to internal mammary artery and saphenous vein. Circulation. 100 (suppl II): II-322-II-327. 11.6;1/72;24.

Shapira OM, Akopian G, Husain A, Adelstein M, Lazar HL, Aldea GS, Shemin RJ. (1999) Improved clinical outcomes in patients undergoing coronary artery bypass grafting with coronary endarterectomy. Ann Thorac Surg. 68: 2273-8. 2.2;24/72;9

Shapira OM, Alkon JD, Macron DSF, Keaney JF, Vita JA, Shemin RJ. (2000) Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm – A prospective randomized study. Ann Thorac Surg. 70: 883-889. 2.2;24/72;17.

Lazar HL, Fitzgerald CA, Ahmed T, Bao Y, Colton T, Shapira OM, Shemin RJ. (2001) Early discharge following coronary artery bypass graft surgery: Are patients really going home earlier? J. Thorac Cardiovasc Surg. 121: 943-950. 3.7;9/72;14.

Kaushal S, Emiel G, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff, Mayer JE. (2001) Circulating endothelial cells for tissue-engineering small blood vessels. Nature Med. 9: 1035-1038. 28.9;1/72;183

Shapira OM, O’Gara P, Roy-Cutter S, Lazar HL, Shemin RJ. (2000) Heparin-bonded cardiopulmonary bypass circuits reduce bleeding and transfusion requirements in proximal aortic surgery. J Cardiac Surg. 15: 229-238. 0.8;61/72

O`Gara PJ, Natarajan V, Husain A, Shapira OM, Shemin RJ. (2002) Clinical outcomes of on-pump coronary bypass using heparin-bonded circuits and reduced anticoagulation compare favorably with off-pump approach. Perfusion. 17:91-4. 0.3;–;1

Lilly KJ, O`Gara PJ, Treanor PR, Crowley R, Reardon DL, Shapira OM, Khuri SF, Aldea GS, Shemin RJ. (2002) Heparin-bonded circuits without a cardiotomy: a description of a minimally invasive technique of cardiopulmonary bypass. Perfusion. 17:95-7. 0.3;–;2.

Ekery DL, Davidoff R, Orlandi QG, Apstein CS, Hesselvik JF, Shemin RJ, Shapira OM. (2003) Diastolic dysfunction after coronary artery bypass grafting: A frequent finding of clinical significance not influenced by intravenous calcium. AHJ. 145:896-902. 3.5;12/72;2.

Shemin RJ, Shapira OM, Pawar RV, Bao Y, Sayeed-Shah U, Lazar HL. (2003) U-ClipÔ anastomosis in coronary artery bypass grafting – Initial clinical experience. Heart Surg For.6:362-5. 0.9;–;2

Shapira OM, Natarajan V, Kaushik S, DeAndrade KM, Shemin RJ. (2004) Off-pump vs. on-pump reoperative CABG via a left thoracotomy for circumflex coronary artery revascularization. J Cardiac Surg. 19:113-118. 0.8;61/72;1

Shapira OM, Eskenazi B, Murphy R, Anter E, Bao Y, Lazar HL, Shemin RJ, Hunter CT. (2004) Endoscopic radial artery harvest for coronary artery bypass grafting – Initial clinical experience. Heart Surg For. 7:E411-E415. 0.9;–;2.

Anter E, Thomas SR, Vita JA, Shapira OM, Keaney JF. (2004) Activation of eNOS by p38 MAP Kinase in response to black tea polyphenols. J Biol Chem, 279:46637-46643. 5.9;33/261;13

Anter E, Chen K, Shapira OM, Karas RH, Keaney JF. (2005) p38 Mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor α dependent pathway in response to black tea polyphenols. Circ Res. 96:1072-1078. 9.4;2/72;6.

Shapira OM, Eskenazi BR, Anter E, Joseph L, Christensen TG, Hunter CT, Lazar HL, Vita JA, Shemin RJ, Keaney JF, Jr.(2006) Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting – Functional and histological assessment of the conduit. J Thorac Cardiovasc Surg, 131:388-94. 3.7;9/72;1.

Shapira OM, Eskenazi BR, Hunter CT, Anter E, Korach A, Anter E, Lazar HL, Shemin RJ. (2006) Dual-beam ultrasound versus transit-time flow meter for intraoperative graft flow measurement during coronary artery bypass grafting. Innovations.1:131-6. 2.9

Shapira OM, Hunter CT, Anter E, Bao Y, DeAndrade K, Lazar HL, Shemin RJ. (2006) Coronary artery bypass grafting in patients with severe left ventricular dysfunction – Early and mid-term outcomes. J Cardiac Surg. 21:225-232. 0.8;61/72

Shapira OM, Eskenazi BR, Hunter CT, Anter E, Bao Y, Murphy R, Lazar HL, Shemin RJ. (2006) Endoscopic versus conventional radial artery harvest – Is smaller better? J Cardiac Surg, 21:329-35. 0.8;61/72

Amiel GE, Komura M, Shapira OM, Yoo JJ, Yazdani S, Berry J, Kaushal S, Bischoff J, Atala A, Soker S. (2006) Engineering of blood vessels from acellular collagen matrices coated with human endothelial cells. Tissue Engin, 12:2355-65. 2.9;31/40

Korach A, Menon P, Dhadly M, Raby K, Shemin RJ, Shapira OM. (2006) Anomalous left main coronary artery from the main pulmonary artery in an elderly patient. Ann Thorac Surg, 82:2285-7. 2.2;24/72

Tsang MW, Davidoff R, Korach A, Apstein CS, Hesselvik JF, Nguyen H, Shemin RJ, Shapira OM. (2007) Diastolic dysfunction after coronary artery bypass grafting: effect of Glucose-Insulin-Potassium infusion. J Cardiac Surg, 22:1-7. 0.8;61/72

Lazar HL, Keilani T, Fitzgerald CA, Shapira OM, Hunter CT, Shemin RJ, Marsh HC, Ryan US, (2007) and the TP-10 Cardiac Surgery Study Group. Beneficial effects of complement inhibition with soluble complement receptor 1 (TP-10) during cardiac surgery: Is there a gender difference? Circulation, 116[Suppl I]:I-83-I-88. 11.6;1/72

Korach A, Shapira OM. (2007) Patch aortoplasty for attachment of coronary artery bypass grafts in patients with complex aortic root pathology. Ann Thorac Surg, accepted for publication. 2.2;24/72

Case Reports

Shapira OM, Mavor E, Pfeffermann R. (1989( Retroperitoneal desmoid tumor in a patient with familial polyposis coli. Harefuah. 116: 98-101. citations – 3

Shapira OM, Bar-On E, Sagiv S, Malkin C. (1990) Disseminated gonococcal infection. J Am Ger Soc. 38: 678-679. 3.5;–;2.

Shapira OM, Simon D, Pfeffermann R. (1990) Gastrointestinal bleeding and ascending biliary infection secondary to a duodenal diverticulum. Harefuah. 119: 267-269.

Shapira OM, Feld S, Mor E, Konichezky S. (1991) Impaired water homeostatis following mixed carbamazepine and phenobarbital overdose. DICP Ann Pharmacother.25: 354-356. 1.8;–;1.

Shapira OM, Simon D, Rothstein H, Pfeffermann R.(1992) Rupture of hepatic echinococcal cyst by minimal blunt abdominal trauma. Harefuah. 122: 80-83.

Shapira OM, Mavor E, Simon D, Rothstein H, Pfeffermann R. (1992) Multiple giant gastrointestinal diverticula complicated by perforated jejuno-ileal diverticulitis in Marfan syndrome. Digest Surg. 9: 58-60. 1.1;64/139

Shapira OM, Simon D, Rothstein H, Mor E, Pfeffermann R. (1992) Unilateral ureteral obstruction secondary to rupture of liver echinococcal cyst. J Urol.148: 1888-1889. 3.6;7/20

Shapira OM, Kagan A, Simon D, Pfeffermann R, Bar-Khayim Y. (1993) Delayed decubitus perforation of the bowel by long-term peritoneal dialysis catheter. A case report with review of the literature. Digest Surg. 9: 332-334. 1.1;64/139;3.

Shapira OM, Aldea GS, Kupferschmid J, Shemin RJ. (1993) Delayed perforation of the esophagus by a closed thoracostomy tube. Chest. 104: 1897-1898. 4.0;3/20;8.

Shapira OM, Williamson WA.(1993) Papillary fibroelastoma of the mitral valve. A case report with review of the literature. Cardiovasc Surg 1: 599-601. 0.8;51/72;11.

Kupferschmid JP, Quist WC, Shapira OM, Shemin RJ. (1994) Descending aortic dissection originating from a juxtaductal traumatic aneurysm. J Cardiac Surg. 9: 65-69. 0.8;61/72

Shapira OM, Aldea GS, Carr TG, Shemin RJ. (1994) Thoracotomy for repair of left ventricular aneurysm in a patient coronary artery bypass grafts. Ann Thorac Surg. 58: 153-158. 2.2;24/72;1.

Carr T, Shapira OM, Kupferschmid JP, Birket D, Aldea GS. (1994) Adenocarcinoma of the esophagus in a patient with paraesophageal hernia. Digest Surg. 11: 25-26. 1.1;64/139

Shapira OM, Connelly GP, Aldea GS, Shemin RJ. (1995) Pulmonary venous flow in constrictive pericarditis. Clin Cardiol. 18: 231-233. 1.1;47/72

Shapira OM, Connelly GP, Shemin RJ.(1995) Ischemic papillary muscle dysfunction in an adult with a parachute mitral valve. J Cardiovasc Surg. 36: 163-135. 0.8;60/72

Shapira OM, Gambardella LS, Aldea GS. (1996) Esophageal stricture – A rare complication of endotracheal intubation. J Thorac Cardiovasc Anesth. 10: 785-786. 0.98;52/72

Shapira OM, Shemin RJ. (1997) Aneurysmal coronary artery disease – Atherosclerotic coronary artery ectasia or adult Kawasaki disease? Chest. 111: 796-799. 4.0;3/20;8.

Moraes D, Philippides GJ, Shapira OM. (1998) Papillary fibroelastoma of the mitral valve with systemic embolization. Circulation. 1251-1252. 11.6;1/72

O’Gara PJ, Aldea GS, Shemin RJ, Shapira OM. (1999) Heparin-bonded circuit with low systemic anticoagulation in a patient with heparin induced thrombocytopenia: a case report. J Extracorp Technol. 31: 142-144.

Howard RA, Aldea GS, Shapira OM, Kasznica JM, Davidoff R. (2000) Concomitant mitral valve myxoma and papillary fibroelsatoma. Ann Thorac Surg. 70: 336. 2.2;24/72

Wilson K, Guardino J, Shapira OM. (2001) Pulmonary tumor embolism as a presenting feature of cavo-atrial hepatocellular carcinoma. Chest. 119: 657-658. 4.0;3/20;2

Korach A, Hunter CT, Lazar HL, Shemin RJ, Shapira OM. (2006) OPCAB for acute LAD dissection due to blunt chest trauma. Ann Thorac Surg, 82:312-4. 2.2;24/72;1.

Korach A, Menon P, Dhadly M, Raby K, Shemin RJ, Shapira OM. (2006) Anomalous left main coronary artery from the main pulmonary artery in an elderly patient. Ann Thorac Surg, 82:2285-7. 2.2;24/72

Sinha P, Varma V, Korach A, Shapira OM. (2007) Transmitral endocavitary repair of inferior left ventricular pseudoaneurysm – A simplified approach in patients requiring concomitant mitral valve surgery. J Thorac Cardiovasc Surg, accepted for publication. 3.7;9/72;1.

Images

Shapira OM, Davidoff R. (1998) Left main coronary artery obstruction in aortic dissection. Circulation. 98: 278-280. 11.6;1/72

Shapira OM, Kasznica JM. (2003) Spindle cell thymoma. N Engl J Med. 349:1442. 44.0;1/105

Letters

Shapira OM, Pfeffermann R. (1992) Anaphylactic shock after traumatic rupture of splenic echinococcal cyst. Letter. Harefuah. 123: 152.

Shapira OM, Mashiah A. (1993) Screening for abdominal aortic aneurysms. Letter. Harefuah. 124: 181.

Shahian DM, Shapira OM.(1994) Postpneumonectomy pulmonary edema or microembolism? Ann Thorac Surg. 57: 524. 2.2;24/72

Shapira OM. (1998) Repair of left ventricular aneurysm. Letter. Ann Thorac Surg. 65: 602. 2.2;24/72

Shapira OM. (1998) Reduction of allogeneic blood transfusions after open-heart operations by lowering cardiopulmonary bypass prime volume. Letter. Ann Thorac Surg. 66: 987-988. 2.2;24/72;1.

Shapira OM. (2001) Cost analysis of diltiazem and nitroglycerin for prevention of coronary bypass conduit spasm. Letter. Ann Thorac Surg. accepted for publication. 2.2;24/72

Reviews, commentaries, hypotheses, editorials

Shapira OM, Shahian DM. (1993) Postpneumonectomy pulmonary edema. Current review. Ann Thorac Surg. 56: 190-195. 2.2;24/72;22.

Shapira OM, Aldea GS. (1993) The role of surgery in small cell lung cancer. Harefuah. 125: 370-375.

Howard RA, Aldea GS, Shapira OM, Kasznica JM, Davidoff R.(1999) Papillary fibroelastoma – increasing recognition of a surgical disease. Current Review. Ann Thorac Surg. 68: 1881-5. 2.2;24/72;30.

Shapira OM. (2000) Differential effects of calcium channel antagonists in the amelioration of radial artery vasospasm. Commentary. Ann Thorac Surg. 69: 1040-1. 2.2;24/72

Shapira OM. (2001) Aortic root replacement versus aortic valve replacement: A case match study. Invited commentary. Ann Thorac Surg, Internet edition, July 2.2;24/72

Lilly KJ, O`Gara PJ, Treanor PR, Reardon D, Crowley R, Hunter C, Shapira OM, Aldea GS, Lazar HL, Shemin RJ. (2004) Cardiopulmonary bypass: it’s not the size, it’s how you use it! Review of a comprehensive blood-conservation strategy. J Extra Corpor Technol, 36:263-8.

Shapira OM. (2007) Impact of patient and target-vessel characteristics on arterial and venous bypass graft patency: Insight from a randomized trial. Desai ND, et al. Commentary. Comp Cardiol Can, 2:32.

Shapira OM, Korach A.(2007) Evolution of the coronary artery bypass grafting conduit. Curr Probl in Cardiol, accepted for publication. 3.6;10/72

Shapira OM. (2007) A safe technique of exposing of a “hidden” left anterior descending artery. Apostolakis E, et al. Commentary. J Cardiac Surgery, 22:507. 0.8;24/72

Published Abstracts

Shapira OM, Davidoff R, Hilkert RJ, Aldea GS, Fitzgerald C, Shemin RJ. (1996) Repair of left ventricular aneurysm – clinical and echocardiographic long-term results of plication versus endoaneurysmorrhaphy. (Abstract) J Am Coll Cardiol. 27: 73A. 9.2;3/72

Shapira OM, Aldea GS, Fitzgerald C, DeAndrade K, Lazar HL, Shemin RJ. (1996) Heparin-bonded cardiopulmonary bypass circuits in valve surgery – reduced bleeding and improved clinical outcome. (Abstract) Israel J Med Sci. 32: 954. 0.5

Shapira OM, Aldea GS, Lazar HL, Shemin RJ. (1996) Valve surgery in the elderly – improved clinical results. (Abstract) Israel J Med Sci. 32: 998. 0.5

Shapira OM, Kelleher RM, Zelingher J, Whalen D, Fitzgerald C, Aldea GS, Lazar HL, Shemin RJ. (1997) Quality of life after valve surgery in patients over the age of 75. (Abstract) J Am Coll Cardiol. 29: 181A. 9.2;3/72

Joseph LN, Babikian VL, Shapira OM, Wijman CA, Lindem KL, White RF, Aldea GS. (1997) Coronary artery bypass grafting: Neurological and neuropsychological outcomes. J Stroke Cerebrovasc Dis (Abstract) 6:474A. 4.0

Shapira OM, Treanor P, Chartrand R, DeAndrade K, Aldea GS, Shemin RJ. (1997) Lowering cardiopulmonary bypass prime volume reduces blood transfusions after open heart surgery – A prospective randomized study (Abstract), Chest. 112 (Suppl): 78S. 4.0;3/20

Aldea GS, Shapira OM, Jacobs AK, O’Gara P, Lazar HL, Ryan T, Shemin RJ. (1997) Effect of gender on postoperative outcome and hospital stay following CABG (Abstract). Circulation. 96 (Suppl I): I-370. 11.6;1/72

Orlandi QG, Davidoff R, Aldea GS, Apstein CS, Pimental D, Hesselvik JF, Shemin RJ, Shapira OM. (1998) Diastolic dysfunction post coronary bypass grafting: A consistent finding of clinical relevance. J Am Coll Cardiol. 36 (Suppl A): 426A. 9.2;3/72

Shapira OM, Xu A, Aldea GS, Shemin RJ, Keaney JF. (1998) Superior Nitric-oxide dependent relaxation of radial artery compared to internal mammary artery and saphenous vein. Circulation. 98 (Suppl I): I-407. 11.6;1/72;1.

Shapira OM, Hana R, Pfeffermann RA, Shemin RJ, Cohen IR. (1998)Prolongation of skin and cardiac allograft survival by treatment with low molecular weight heparin. Chest. 114 (Suppl): 284S. 4.0;3/20

Shapira OM, Xu A, Vita JA, Aldea GS, Shah N, Shemin RJ, Keaney JF. (1998) Nitroglycerin is superior to Diltiazem in preventing arterial coronary bypass conduit spasm. Circulation. 98 (Suppl I): I-407. 11.6;1/72

Wijman CAC, Schuble B, Vakili K, Aldea GS, Shapira OM, Winter M, Babikian V. (1998) Cerebral hemodynamic changes during bypass graft surgery. Ann Neurol. 44: 494. 7.2

Wijman CAC, Babikian VL, Aldea GS, Shapira OM, Cantelmo NL, Winter MR. (1986) A comparison of cerebral hemodynamic changes in CABG surgery and carotid endarterectomy. Ann Thorac Surg. 66: 1495. 2.2;24/72

Orlandi QG, Davidoff R, Aldea GS, Apstein CS, Pimental D, Hesselvik JF, Shemin RJ, Shapira OM. (1998) Diastolic dysfunction post coronary bypass grafting: a consistent finding of clinical relevance. J Am Soc Echocardiography. 11: 542. 1.5;37/72

Leopold JA, Aldea GS, Cupples A, Shapira OM, Ryan TJ, Jacobs AK. (1993) Coronary revascularization in the elderly: contemporary experience. J Am Coll Cardiol. 33 (Suppl A): 94A. 9.2;3/72

Shapira OM, Akopian G, Aldea GS, Adelstein M, Lazar HL, Shemin RJ. (1993) Improved clinical outcomes in patients undergoing coronary artery bypass grafting with coronary endarterectomy. J Am Coll Cardiol. 33 (Suppl A): 567A. 9.2;3/72

Orlandi QR, Davidoff R, Adelstein M, Pimental D, Hesselvick JF, Aldea GS, Shemin RJ, Shapira OM. (1999) Diastolic dysfunction post coronary bypass grafting: The importance of extra-cardiac factors. J Am Soc Echocardiography. 12: 392. 1.5;37/72

Ekery DL, Shapira OM, Orlandi QG, Apstein CS, Hesselvik JF, Shemin RJ, Davidoff R. (2000) Diastolic dysfunction after coronary artery bypass grafting: A universal finding of clinical significance. J Am Soc Echocardiography. 13:351. 1.5;37/72

Shapira OM, Natarajan V, Kausgik S, DeAndrade KM, Shemin RJ. (2000) Off-pump vs. on-pump reoperative CABG via a left thoracotomy for circumflex coronary artery revascularization. J Cardiovasc Eng. 5: 118

Shapira OM, Ekery D, Hesselvick F, Apstein C, Davidoff R. (2000) Deleterious effect of coronary bypass grafting on left ventricular diastolic function – A universal finding not influenced by intravenous calcium. J Cardiovasc Eng. 5: 111.

Hesselvick JF, Gonzales M, Ortega R, Pierce E, Shapira OM. (2000) Transesophageal atrial and ventricular pacing using an octapolar sheet electrode. Anesthesiology. 93:382. 4.0

Tsang MW, Davidoff R, Apstein C, Hesselvick F, Nguyen H, Shemin RJ, Lazar HL, Shapira OM. (2001) Diastolic Dysfunction Post CABG – Effect of Glucose-Insulin-Potassium infusion. J Am Soc Echocardiography. 14: 495 1.5;37/72

Anter E, Chen K, Shapira OM, Keaney JF. (2004) p38 mitogen-activated protein kinase transactivates estrogen receptor alpha leading to eNOS stimulation by black tea polyphenols. JFRBM 37:578. citation- 1

Samy SA, Eskenazi B, Hunter CT, Bao Y, Lazar HL, Shemin RJ, Shapira OM.(2005) Endoscopic vs. conventional radial artery harvest – Initial clinical experience. Current Surgery. 62:209-210.

Lazar HL, Keilani T, Fitzgerald CA, Shapira OM, Hunter CT, Shemin RJ, Marsh HC Jr, Ryan US. (2006) Beneficial effects of complement inhibition with TP-10 during cardiac surgery: Is there a gender difference? Circulation. 114 suppl II:II-712. 11.6;1/72

Shapira OM, Korach A, Benjamin E, Lovett A, Silverstein T, Agnihotri AK, Torchiana DF, Shemin RJ, Normand SL. (2006) The impact of race and insurance status on utilization rates and outcomes after coronary artery bypass grafting surgery in the Commonwealth of Massachusetts. Circulation. 114 suppl II:II-860. 11.6;1/72

Nguyen HG, Korach A, Collura C, Keaney J Jr, Shapira OM. (2007) Differential effects of natriuretic peptides on arterial and venous coronary artery bypass conduits. Circulation, 116 suppl II;II-443-II-444. 11.6;1/72

Participation in Scientific Conferences, Lectures, and Other Activity

Shapira OM, Rothstein H, Simon D, Pfeffermann R. Rupture of liver echinococcal cyst with minimal trauma. The Stephan Landes Annual Trauma Meeting. 1986.

Shapira OM, Simon D, Rothstein H, Mavor E, Pfeffermann R. Symptomatic hernia. The Annual Meeting of the Israel Surgical Society, 1987.

Shapira OM, Simon D, Mavor E, Hana R, Pfeffermann RA. Low anterior resection for rectal adenocarcinoma. 16th European Federation Congress of the International College of Surgeons, 1989.

Shapira OM, Simon D, Rothstein H, Mavor E, Pfeffermann R. “Acute on acute” symptomatic hernia. 16th European Federation Congress of the International College of Surgeons, 1989.

Shapira OM, Wasserman JP, Barzili N, Pasik S, Mashiah A. Ultrasound screening for abdominal aortic aneurysms in patients with atherosclerotic peripheral vascular disease. 15th World Congress of the Israel Medical Association, 1991.

Shapira OM, Aldea GS, Fonger JD, Shemin RJ. Thoracoscopy in the diagnosis and management of pericardial effusions in patients with advanced malignancy. Annual Fall Meeting of the New England Cancer Society, 1992.

Shapira OM, Shemin RJ. Aortic valve replacement with cryopreserved allografts – Mid-term results. Annual Meeting of The New England Surgical Society, 1993.

Shapira OM, Lazar HL, Aldea GS, Fonger JD, Shemin RJ. Emergency coronary artery bypass graft surgery following failed percutaneous transluminal coronary angioplasty. 4th World Congress of the International Society of Cardio-Thoracic Surgeons, 1994.

Shapira OM, Shemin RJ. Aortic valve replacement with cryopreserved allografts. 4th World Congress of the International Society of Cardio-Thoracic Surgeons, 1994.

Shapira OM, Mor E, Reshef T, Pfeffermann RA, Cohen IR. Prolongation of cardiac allograft survival by T-Cell vaccination. 4th World Congress of the International Society of Cardio-Thoracic Surgeons, 1994.

Shemin RJ, Shapira OM. Aortic root replacement with cryopreserved allografts – operative technique. Video presentation, 4th World Congress of the International Society of Cardio-Thoracic Surgeons, 1994.

Shapira OM, Fonger JD, Reardon K, Shemin RJ. Unexplained fever following aortic valve replacement with cryopreserved allografts. VI International Symposium Cardiac Bioprostheses, 1994.

Connelly G, Arkoff H, Davidoff R, Shapira OM, Aldea GS, Shemin RJ. Intraoperative transesophageal echocardiography for aortic annular measurement and the selection and preparation of aortic valve allografts. Annual Meeting of the American Society of Anesthesiology, 1994.

Aldea GS, Doursounian M, O’Gara P, Treanor P, Shapira OM, Lazar HL, Shemin RJ. Heparin-bonded cardiopulmonary bypass circuits and a reduced anticoagulation protocol in patients undergoing primary CABG: A prospective randomized study. Annual Meeting of the Society of Thoracic Surgeons, 1996.

Shapira OM, Davidoff R, Hilkert RJ, Aldea GS, Fitzgerald C, Shemin RJ. Repair of left ventricular aneurysm – clinical and echocardiographic long-term results of plication versus endoaneurysmorrhaphy. Annual Meeting of the American College of Cardiology, 1996.

Aldea GS, Doursounian M, O’Gara P, Treanor P, Shapira OM, Lazar HL, Shemin RJ. Heparin-bonded circuits with a reduced anticoagulation protocol improve clinical outcomes in patients undergoing primary CABG. A prospective randomized study. Annual Meeting of the Western Thoracic Surgical Association, 1996.

Shapira OM, Aldea GS, Lazar HL, Shemin RJ. Heparin-bonded cardiopulmonary bypass circuits in valve surgery. The American Society of Extracorporeal Technology Fall Meeting, 1996.

Shapira OM, Aldea GS, Fitzgerald C, DeAndrade K, Lazar HL, Shemin RJ. Heparin-bonded cardiopulmonary bypass circuits in valve surgery – reduced bleeding and improved clinical outcome. 9th Annual Meeting Mediterranean Association of Cardiology and Cardiac Surgery, 1996.

Shapira OM, Aldea GS, Lazar HL, Shemin RJ. Valve surgery in the elderly – improved clinical results. 9th Annual Meeting Mediterranean Association of Cardiology and Cardiac Surgery, 1996.

Shapira OM, Kelleher RM, Zelingher J, Wahlen D, Fitzgerald C, Aldea GS, Lazar HL, Shemin RJ. Quality of life after valve surgery in patients over the age of 75. American College of Cardiology 46th Annual Scientific Session, 1997.

Joseph LN, Babikian VL, Shapira OM, Wijman CA, Lindem KL, White RF, Aldea GS. Coronary Artery Bypass Grafting: Neurological and neuropsychological outcomes. Annual North American Stroke Meeting, 1997.

Shapira OM, Treanor P, Chartrand R, DeAndrade K, Aldea GS, Shemin RJ. Lowering cardiopulmonary bypass prime volume reduces blood transfusions after open-heart surgery – A prospective randomized study. Chest – Annual Meeting of the American College of Chest Physicians, 1997.

Aldea GS, Shapira OM, Jacobs AK, O’Gara P. Lazar HL, Ryan T, Shemin RJ. Effect of gender on postoperative outcome and hospital stay following CABG. The 70th Scientific Session of the American Heart Association, 1997.

Orlandi QG, Davidoff R, Aldea GS, Apstein CS, Pimental D, Hesselvik JF, Shemin RJ, Shapira OM. Diastolic dysfunction post coronary bypass grafting: A consistent finding of clinical relevance. The 47th Annual Scientific Session of the American College of Cardiology, 1998.

Aldea GS, Shapira OM, Jacobs A, Lazar HL, Shemin RJ. Comparison of risk profile and outcomes in patients undergoing surgical and catheter based revascularization. The 34th Annual Meeting of the Society of Thoracic Surgeons, 1998.

Shapira OM, Aldea GS, Cutter S, Fitzgerald C, Lazar HL, Shemin RJ. Surgery of the proximal aorta – 10-year experience in 108 patients. Aortic Surgery Symposium VI, 1998.

Orland QG, Davidoff R, Aldea GS, Apstein CS, Pimental D, Hesselvik JF, Shemin RJ, Shapira OM. Diastolic dysfunction post coronary bypass grafting. 9th Annual Scientific Sessions of the American Society of Echocardiography, 1998.

Wijman CAC, Babikian VL, Aldea GS, Shapira OM, Cantelmo NL, Winter MR, Pochay VE. A comparison of cerebral hemodynamic changes in CABG surgery and carotid endarterectomy. 98 Outcomes. The Key West Meeting, 1998.

Shapira OM, Hana R, Pfeffermann RA, Shemin RJ, Cohen IR. Prolongation of rat cardiac allograft survival by recipient treatment with mini doses of low molecular weight heparin. 32nd Annual Meeting of the Association for Academic Surgery, 1998.

Shapira OM, Xu A, Aldea GS, Shemin RJ, Keaney JF. Superior Nitric-oxide dependent relaxation of radial artery compared to internal mammary artery and saphenous vein. 71st Scientific Session of the American Heart Association, 1998.

Shapira OM, Hana R, Pfeffermann RA, Shemin RJ, Cohen IR. Prolongation of skin and cardiac allograft survival by treatment with low molecular weight heparin. 64th Annual Scientific Assembly of the American of the American College of Chest Physicians, 1998.

Shapira OM, Xu A, Vita JA, Aldea GS, Shah N, Shemin RJ, Keaney JF. Nitroglycerin is superior to Diltiazem in preventing arterial coronary bypass conduit spasm. 71st Scientific Sessions of the American Heart Association, 1998.

Wijman CAC, Schauble B, Vakili K, Aldea GS, Shapira OM, Winter M, Babikian V. Cerebral hemodynamic changes during bypass graft surgery. 123d Annual Meeting of the American Neurological Association, 1998.

Leopold JA, Aldea GS, Cupples A, Shapira OM, Ryan TJ, Jacobs AK. Coronary revascularization in the elderly: contemporary experience. 48th Annual Scientific Session of the American College of Cardiology, 1999.

Shapira OM, Akopian G, Aldea GS, Adelstein M, Lazar HL, Shemin RJ. Improved clinical outcomes in patients undergoing coronary artery bypass grafting with coronary endarterectomy. 48th Annual Scientific Session of the American College of Cardiology, 1999.

Shapira OM, Alkon JD, Chartrand R, DeAndrade K, Roy-Cutter S, Whalen D, Lazar HL, Shemin RJ. Prognosis and quality of life after CABG in the elderly. 1st International Congress on Heart Disease, 1999.

Orlandi QR, Davidoff R, Adelstein M, Pimental D, Hesselvick JF, Aldea GS, Shemin RJ, Shapira OM. Diastolic dysfunction post coronary bypass grafting: The importance of extra-cardiac factors. The 10th Annual Scientific Sessions of the American Society of Echocardiography, 1999.

Shapira OM, Alkon JD, Macron DS, Keaney JF, Vita JA, Aldea GS, Shemin RJ. Nitroglycerin is superior to diltiazem for prevention of coronary bypass conduit spasm – A prospective randomized study. The 36th Annual Meeting of the Society of Thoracic Surgeons, 2000.

Lazar HL, Fitzgerald CA, Ahmed T, Bao Y, Shapira OM, Shemin RJ. Early discharge following coronary artery bypass graft surgery: Cost saving or cost shifting? The 80th Annual Meeting of the American Association of Thoracic Surgery, 2000.

Shapira OM, O’Gara P, Roy-Cutter S, Lazar HL, Shemin RJ. Heparin-bonded cardiopulmonary bypass circuits reduce bleeding and transfusion requirements in proximal aortic surgery. Aortic Surgery Symposium VII, 2000.

Ekery DL, Shapira OM, Orlandi QG, Apstein CS, Hesselvik JF, Shemin RJ, Davidoff R. Diastolic dysfunction after coronary artery bypass grafting: A universal finding of clinical significance. Am Soc Echocardiography, 2000.

Shapira OM, Natarajan V, Kaushik S, DeAndrade KM, Shemin RJ. Off-pump vs. on-pump reoperative CABG via a left thoracotomy for circumflex coronary artery revascularization. 10th World Congress of the World Society Cardiothoracic Surgeons, 2000.

Shapira OM, Ekery D, Hesselvick F, Apstein C, Davidoff R. Deleterious effect of coronary bypass grafting on left ventricular diastolic function – A universal finding not influenced by intravenous calcium. 10th World Congress of the World Society Cardiothoracic Surgeons, 2000.

Hesselvick JF, Gonzales M, Ortega R, Pierce E, Shapira OM. Transesophageal atrial and ventricular pacing using an octapolar sheet electrode. Annual Meeting of the American Society of Anesthesiology, 2000.

Theodore AC, Hurley J, Shapira OM, Brazer W, Terwilliger EF, Cruikshank WW. Prolongation of skin graft survival by interleukin-16. Annual Meeting of the American Thoracic Society, 2001.

O’Gara PJ, Natarajan V, Lilly K, Husain A, De la Torre R, Shapira OM, Lazar HL, Shemin RJ. Clinical outcomes of on-pump coronary bypass using heparin-bonded circuits and reduced anticoagulation compare favorably with off-pump approach. The Annual Meeting of the American Academy of Cardiovascular Perfusion, 2001.

Tsang MW, Davidoff R, Apstein C, Hesselvik F, Nguyen H, Shemin RJ, Lazar HL, Shapira OM. Diastolic dysfunction post CABG – Effect of Glucose-Insulin-Potassium infusion. Annual Meeting of the American Society of Echocardiography, 2001.

Shapira OM, Amiel GE. Teaching breaking bad news in US Cardiac Surgery training program – program directions perspective. The Technion School of Medicine Annual Conference on doctor – patient relationship, 2001.

Shandre A, Zisman E, Pizov R, Zlotnick AY, Shapira OM, Ammar R. Effects of intranthecal morphine for postoperative analgesia following MIDCAB. The 49th Annual Meeting of The Israel Heart Society together with The Israel Society of Cardiothoracic Surgery, 2002.

Sawaed S, DeAndrade K, Sachner R, Gurevitz J, Sarapov I, Safadi T, Ammar R, Shemin RJ, Shapira OM. CABG in patients with severe left ventricular dysfunction: experience in 115 cases. The 49th Annual Meeting of The Israel Heart Society together with The Israel Society of Cardiothoracic Surgery, 2002.

Shapira OM, Shemin RJ, Pawar RV, Bao Y, Sayeed-Shah U, Lazar HL. U-ClipÔ anastomosis in coronary artery bypass grafting – Initial clinical experience. CTT – Cardiothoracic Surgery Techniques and Technologies, 2003.

Shapira OM. Endoscopic radial artery harvest. Cardiac Surgery Beyond 2003. 12th International Symposium of the International Society of Extracorporeal Technology, 2003.

Anter E, Thomas SR, Vita JA, Shapira OM, Keaney JF. Black tea polyphenols induce eNOS activation via a phosphatidylinositol 3-kinas / Akt pathway in a calcium-dependent mechanism. 10th Annual meeting of the Society of Free Radical Biology and Medicine, 2003.

Hunter CT, Eskenazi B, Murphy R, Bao Y, Lazar HL, Shemin RJ, Shapira OM. Endoscopic radial artery harvest for coronary artery bypass grafting – Initial clinical experience. CTT – Cardiothoracic Surgery Techniques and Technologies, 2004.

Samy SA, Eskenazi B, Hunter CT, Bao Y, Lazar HL, Shemin RJ, Shapira OM. Endoscopic vs. conventional radial artery harvest – Initial clinical experience. 11th Annual Surgical New England Resident and Fellow Research Meeting, 2004.

Shapira OM, Gorman J, Fitzgerald CA, Traylor D, Hunter CT, Lazar HL, Davidson K, Chessare J, Shemin RJ. Process improvement to smooth daily discharge time of patients after cardiac surgery improves patient flow and reduces operating room time. 10th Annual Scientific Symposium at the Institute of Healthcare Improvement, 2004.

Anter E, Chen K, Shapira OM, Keaney JF. p38 mitogen-activated protein kinase transactivates estrogen receptor alpha leading to eNOS stimulation by black tea polyphenols. 11th Annual meeting of the Society of Free Radical Biology and Medicine, 2004.

Shapira, OM. Radial artery vs. saphenous vein for coronary artery bypass grafting. Panel Discussion. The 41st Annual Meeting of the Society of Thoracic Surgeons, 2005.

Shapira OM, Eskenazi BR, Hunter CT, Anter E, Murphy R, Lazar HL, Shemin RJ. Dual-beam ultrasound versus transit-time flow meter for intraoperative graft flow measurement during coronary artery bypass grafting. ISMICS 05, The Annual Meeting of the International Society of Minimally Invasive Cardiothoracic Surgery and Cardiothoracic Technique and Technologies, 2005.

Shapira OM, Eskenazi BR, Anter E, Collura CV, Joseph L, Hunter CT, Lazar HL, Vita JA, Shemin RJ, Keaney JF. Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting – Functional and histological assessment of the conduit. The 31st Annual Meeting, Western Thoracic Surgical Association, 2005.

Samy SA, Lazar HL, Shapira OM, Hunter CT, Shemin RJ. The treatment of atrial fibrillation using a novel energy source, high intensity focused ultrasound. Annual Meeting of the New England Surgical Society, 2005.

Korach A, Menon P, Dhadly M, Raby K, Shemin RJ, Shapira OM. Anomalous left main coronary artery from the main pulmonary artery in an elderly patient. The 42nd Annual Meeting of the Society of Thoracic Surgeons, 2006.

Komura M, Eberli D, Amiel GE, Shapira OM, Yoo JJ, Soker S, Atala A. Bioengineered blood vessles for renal artery graft surgery. The 70th Annual Meeting of the Southeastern Section of the American Urological Association, 2006.

64. Shapira OM, Korach A, Bao Y, Hunter CT, Lazar HL, Shemin RJ. Minimally invasive versus conventional aortic valve replacement – A 10-year experience. ISMICS 06, The Annual Meeting of the International Society of Minimally Invasive Cardiothoracic Surgery, 2006.

65. Lazar HL, Keilani T, Fitzgerald CA, Shapira OM, Hunter CT, Shemin RJ, Marsh HC Jr, Ryan US. Beneficial effects of complement inhibition with TP-10 during cardiac surgery: Is there a gender difference? The Annual Scientific Sessions of the American Heart Association, 2006.

Shapira OM, Korach A, Benjamin E, Lovett A, Silverstein T, Agnihotri AK, Torchiana DF, Shemin RJ, Normand SL. The impact of race and insurance status on utilization rates and outcomes after coronary artery bypass grafting surgery in the Commonwealth of Massachusetts. The Annual Scientific Sessions of the American Heart Association, 2006.

Nguyen HG, Korach A, Collura C, Keaney J Jr, Shapira OM. Differential effects of natriuretic peptides on arterial and venous coronary artery bypass conduits. The Annual Scientific Sessions of the American Heart Association, 2007.

Lazar HL, Joseph L, San Mateo C, Frame J, Bao Y, Hunter CT, Shapira OM, Shemin RJ, Cabral HJ, McDonell M, Chipkin S. Decreased vascular inflammation in the diabetic internal mammary artery: A potential mechanism for enhanced long-term patency. The 44th Annual Meeting of the Society of Thoracic Surgeons, 2008.

Editorial Responsibilities

Editorial Board Member

Journal of Cardiac Surgery
Peer-review –
Circulation
Journal Thoracic and Cardiovascular Surgery
Annals of Thoracic Surgery
Chest
Journal of the American College of Cardiology
Israel Medical Association Journal
Heart Journal on line